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Vaccines
Research from University of Melbourne yields new findings on vaccines
July 8th, 2009
"Successful vaccines function almost exclusively by establishing long-lived plasma cells that secrete antibody into the blood and at mucosal sites," investigators in Melbourne, Australia report. "Some pathogens, such as HIV and the influenza A viruses, use a mutational strategy to escape neutralization by antibodies specific for surface glycoproteins. The CD8(+) cytotoxic T-lymphocyte (CTL) response is, on the other hand, directed mostly at peptides derived from conserved, internal virus proteins," wrote P.C. Doherty and colleagues, University of Melbourne. The researchers concluded: "Can CTL memory be manipulated to provide cross-reactive...
Source: Vaccine Weekly (2009-07-08)
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