Immunization

Research from University of Milan provides new data on immunization

Published in Vaccine Weekly, July 22nd, 2009

According to a study from Milan, Italy, "The group B streptococcus type I pullulanase ( SAP) is a class 13 glycoside hydrolase that is anchored to the bacterial cell surface via a conserved C-terminal anchoring motif and involved in alpha-glucan degradation."

"Recent in vitro functional studies have shown that SAP is immunogenic in humans and that anti-SAP sera derived from immunized animals impair both group A and group B streptococcus pullulanase activities, suggesting that in vivo immunization with this antigen could prevent streptococcal colonization. To further investigate the putative role of SAP in bacterial pathogenesis, we carried out functional studies and...

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Source: Vaccine Weekly (2009-07-22)

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