DNA Vaccines
New DNA vaccines research from University of Barcelona outlined
Published in Vaccine Weekly, July 22nd, 2009
According to a study from Barcelona, Spain, "We have evaluated the effect of mammalian codon optimization on the immunogenicity and protective efficacy of plasmid DNA vaccines encoding pre-erythrocytic stage Plasmodium falciparum and Plasmodium yoelii antigens in mice. Codon optimization significantly enhanced in vitro expression and in vivo antibody responses for P. falciparum circumsporozoite protein (PfCSP) and P. yoelii hepatocyte erythrocyte protein 17 kDa (PyHEP17) but not for P. yoelii circumsporozoite protein (PyCSP)."
"Unexpectedly, more robust CD4(+) and CD8(+) T cell responses as measured by IFN-gamma ELIspot, lymphoproliferation, and cytotoxic T lymphocyte...
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Source: Vaccine Weekly (2009-07-22)
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