According to a study from Barcelona, Spain, "We have evaluated the effect of mammalian codon optimization on the immunogenicity and protective efficacy of plasmidDNA vaccines encoding pre-erythrocytic stage Plasmodium falciparum and Plasmodium yoelii antigens in mice. Codon optimization significantly enhanced in vitro expression and in vivoantibody responses for P. falciparum circumsporozoite protein (PfCSP) and P. yoelii hepatocyteerythrocyte protein 17 kDa (PyHEP17) but not for P. yoelii circumsporozoite protein (PyCSP)."
"Unexpectedly, more robust CD4(+) and CD8(+) T cell responses as measured by IFN-gamma ELIspot, lymphoproliferation, and cytotoxic T lymphocyte...
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