Hepatitis B Virus

Research from B.O. Lee et al broadens understanding of hepatitis B virus

Published in Vaccine Weekly, July 29th, 2009

"Previous studies demonstrated that the. primary APCs for the hepatitis B core Ag (HBeAg) were B cells and not dendritic cells (DC). We now report that splenic B1a and B1b cells. more efficiently present soluble HBcAg to naive CD4(+) T cells than splenic B2 cells," scientists in the United States report.

"This, was demonstrated by direct HBcAg-biotin-binding studies and by HBcAg-specific T cell activation in vitro in cultures of naive HBcAg-specific T cells and resting B cell subpopulations. The inability of DC to function as APCs for exogenous HBcAg relates to lack of uptake of HBcAg, not to processing or presentation, because HBcAg/anti-HBc immune complexes can be...

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Source: Vaccine Weekly (2009-07-29)

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