The Wistar Institute

Penn-Wistar team gains insight into HIV vaccine failure

Published in Vaccine Weekly, August 5th, 2009

PHILADELPHIA - (July 20, 2009) - A team of researchers from The Wistar Institute and the University of Pennsylvania reports new evidence refuting a popular hypothesis about the highly publicized failure in 2007 of the Merck STEP HIV vaccine study that cast doubt on the feasibility of HIV-1 vaccines. The findings were published on-line July 20 in Nature Medicine.

The phase II STEP vaccine trial was stopped after an interim analysis showed no efficacy in preventing HIV infection in at-risk individuals. It was noted that a subset of participants who had previous immunity in the form of neutralizing antibodies to the adenovirus 5 (Ad5) vector used to deliver the vaccine...

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Source: Vaccine Weekly (2009-08-05)

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