Cytomegalovirus
Study results from J.A. Zaia and colleagues broaden understanding of cytomegalovirus
Published in Vaccine Weekly, August 12th, 2009
According to recent research from the United States, "The human cytomegalovirus (CMV) pp65 protein contains two bipartite nuclear localization signals (NLSs) at amino acids (aa) 415 to 438 and aa 537 to 561 near the carboxy terminus of CMV pp65 and a phosphate binding site related to kinase activity at lysine-436. A mutation of pp65 with K436N (CMV pp65mII) and further deletion of aa 537 to 561 resulted in a novel protein (pp65mIINLSKO, where NLSKO indicate NLS knockout) that is kinaseless and that has markedly reduced nuclear localization."
"The purpose of this study was to biologically characterize this protein and its immunogenicity compared to that of native pp65....
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Source: Vaccine Weekly (2009-08-12)
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