Whooping Cough

Studies in the area of whooping cough reported from Y. Lamberti and co-researchers

Published in Vaccine Weekly, August 12th, 2009

"Bordetella pertussis is a re-emerging human respiratory pathogen whose infectious process is not fully understood, hampering the design of effective vaccines. The nature of bacterial attachment to host cells is a key event in the outcome of the infection," investigators in La Plata, Argentina report.

"However, host cell receptors involved in B. pertussis colonization of the respiratory tract are still under investigation. Here, we report that cholesterol-rich domains are involved in B. pertussis adhesion to epithelial cells. Treatment of A549 cells with cholesterol-sequestering drugs such as methyl-beta-cyclodextrin, nystatin, or filipin resulted in a significant...

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Source: Vaccine Weekly (2009-08-12)

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