Hepatitis B Virus

Researchers from National Institutes of Health describe findings in hepatitis B virus

Published in Vaccine Weekly, August 12th, 2009

"The hepatitis B virus (HBV) envelope protein (S) self-assembles into subviral particles used as commercial vaccines against hepatitis B. These particles are excellent carriers for foreign epitopes, which can be inserted into the external hydrophilic loop or at the N- or C-terminal end of the HBV S protein," scientists in the United States report.

"We show here that the N-terminal transmembrane domain (TMD) of HBV S can be replaced by the TMDs of the hepatitis C virus (HCV) envelope proteins El and E2, to generate fusion proteins containing the entire HCV El or E2 sequence that are efficiently coassembled with the HBV S into particles. This demonstrates the remarkable...

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Source: Vaccine Weekly (2009-08-12)

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