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New findings from University of Melbourne in the area of life sciences described

Published in Vaccine Weekly, August 12th, 2009

According to a study from Melbourne, Australia, "Cytotoxic T lymphocyte responses to conserved proteins such as Gag within HIV- or SIV-infected hosts can facilitate partial control of viremia. However, the utility of targeting variable viral proteins by CTL responses is unclear."

"We studied CTL responses to regulatory and accessory proteins of SIV in pigtail macaques. The regulatory and accessory proteins were the most commonly targeted proteins by CTL responses from pigtail macaques. We identified 2 novel Tat-specific CTL responses that were both restricted by the Mane-A*10 allele. Vital escape at one of the Tat epitopes, KSA10, was slower in comparison to another Tat...

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