Cancer Vaccines

Researchers from Kobe University, Medical Department detail findings in cancer vaccines

Published in Vaccine Weekly, August 26th, 2009

According to recent research from Kobe, Japan, "Regulatory T cells (Tregs) play an important role in immunological self-tolerance and protect the host from autoimmune disease. However, in cancer immunity, Tregs might block anti-tumor immune responses."

"Therefore, the depletion of Tregs using a specific agent that suppresses its function or population, such as an anti-CD25 antibody, could promote anti-tumor immune responses. In the present study, a cytotoxicity assay, enzyme-linked immunosorbent spot (ELISPOT) assay and measuring cytokine secretion, were used to study the efficacy of Treg depletion by anti-CD25 antibody added to a dendritic cell/tumor cell (DC/TC)...

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Source: Vaccine Weekly (2009-08-26)

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