Mycobacteria

Studies from National University provide new data on mycobacteria

Published in Vaccine Weekly, September 30th, 2009

"Significant variability in efficacy of live Mycobacterium bovis BCG as a tuberculosis vaccine is observed globally. Effects of pre-vaccination sensitisation to non-tuberculous environmental mycobacteria (Env) are suspected to underlie this phenomenon, but the mechanisms remain unclear," scientists writing in the European Journal of Immunology report.

"We postulated that it could be due to Env-specific T cells exerting cytotoxicity against BCG-infected host cells. After murine sensitisation with heat-killed antigens of different Env species, splenocytes from M. chelonae (CHE)-sensitised mice exerted the strongest cytotoxicity against autologous BCG-infected...

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Source: Vaccine Weekly (2009-09-30)

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