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University of Freiburg reports research in life sciences

Published in Vaccine Weekly, September 30th, 2009

"To study the role of IL-12 as a third signal for T-cell activation and differentiation in vivo, direct IL-12 signaling to CD8(+) T cells was analyzed in bacterial and viral infections using the P14 T-cell adoptive transfer model with CD8(+) T cells that lack the IL-12 receptor. CD8(+) T cells deficient in IL-12 signaling were impaired in clonal expansion after Listeria monocytogenes infection but not after infection with lymphocytic choriomeningitis virus, vaccinia virus or vesicular stomatitis virus," investigators in Freiburg, Germany report.

"Although limited in clonal. expansion after Listeria infection, CD8(+) T cells deficient in IL-12 signaling exhibited normal...

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