Smallpox Vaccines
Research results from Food & Drug Administration update knowledge of smallpox vaccines
Published in Vaccine Weekly, November 4th, 2009
"The immune response elicited by LC16m8, a candidate smallpox vaccine that was developed in Japan by cold selection during serial passage of the Lister vaccine virus in primary rabbit kidney cells, was compared to Dryvax in a mouse model. LC16m8 carries a mutation resulting in the truncation of the B5 protein, an important neutralizing target of the extracellular envelope form of vaccinia virus (EV)," scientists in the United States report.
"LC16m8 elicited a broad-spectrum immunoglobulin G (IgG) response that neutralized both EV and the intracellular mature form of vaccinia virus and provoked cell-mediated immune responses, including the activation of CD4(+) and CD8(+)...
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Source: Vaccine Weekly (2009-11-04)
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