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African Trypanosomiasis
New african trypanosomiasis research from M.S. Silva et al outlined
November 11th, 2009
"African trypanosomiasis (AT), also known as sleeping sickness in humans and Nagana in animals, is a disease caused by the protozoan parasite Trypanosoma brucei. AT is an extremely debilitating disease in human, cattle, and wild animals, and the treatment is difficult with frequent relapses," scientists in Lisbon, Portugal report. "This work shows that BALB-c mice immunized intramuscularly with a single dose (100 mu g) of a plasmid DNA encoding the 5'-terminal region of the trans-sialidase (nTSA) gene of T. brucei brucei are able to produce IgG antibodies that bind to the bloodstream form of T. brucei-protein extract and recognize the recombinant nTSA protein, expressed...
Source: Vaccine Weekly (2009-11-11)
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