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Tuberculosis Vaccines

Reports from Fourth Military Medical University describe recent advances in tuberculosis vaccines

Published in Vaccine Weekly, November 25th, 2009

New investigation results, 'New alternative vaccine component against mycobacterium tuberculosis--heat shock protein 16.3 or its T-cell epitope,' are detailed in a study published in Scandinavian Journal of Immunology. "Heat shock protein 16.3 (Hsp16.3) of Mycobacterium tuberculosis (MTB) containing T-cell and B-cell epitopes not only plays an important role in the survival of MTB against macrophages, but also has great potential to be used to develop new TB vaccines. In order to study whether Hsp16.3 can be replaced with its T-cell epitope for producing a vaccine against TB, we expressed and purified Hsp16.3 protein of MTB H37Rv strain and confirmed by immunoblotting,"...

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