Vaccines

Research on vaccines discussed by scientists at University of Notre Dame

Published in Vaccine Weekly, December 23rd, 2009

"TCR (T-cell receptor) recognition of antigenic peptides bound and presented by MHC (major histocompatibility complex) molecules forms the basis of the cellular immune response to pathogens and cancer. TCRs bind peptide-MHC complexes weakly and with fast kinetics, features which have hindered detailed biophysical studies of these interactions," researchers in the United States report.

"Modified peptides resulting in enhanced TCR binding could help overcome these challenges. Furthermore, there is considerable interest in using modified peptides with enhanced TCR binding as the basis for clinical vaccines. In the present study, we examined how fluorine substitutions in an...

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Source: Vaccine Weekly (2009-12-23)

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