Highly Active Antiretroviral Therapy

Research findings from H.B. Yang et al update understanding of highly active antiretroviral therapy

Published in Vaccine Weekly, December 23rd, 2009

According to a study from Oxford, the United Kingdom, "We investigated whether therapeutic vaccination in highly active antiretroviral therapy (HAART)treated patients with a modified vaccinia virus Ankara-vectored HIV-1 vaccine, with or without therapy interruption, induced the production of interleukin (IL)-10."

"Plasma IL-10 levels were not significantly increased postvaccination, but increased in parallel with viraemia in patients who interrupted therapy. Surprisingly, IL-10 blockade augmented HIV-specific T cell proliferative responses in HAART-suppressed patients but had no effect once virological control was lost," wrote H.B. Yang and colleagues.

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Source: Vaccine Weekly (2009-12-23)

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