Published in Vaccine Weekly, December 30th, 2009
"We, therefore, tested a panel of subgroup C/B chimeric and fiber-modified adenoviruses (Ads) for then relative capacity to transduce human DC. We made use of in vitro generated Langerhans cells, and of ex vivo human skin and melanoma-draining lymph node derived DC. Of the tested viruses the C/B-chimeric adenovirus serotype 5 (Ad5)/3 virus most efficiently transduced in vitro generated Langerhans...
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