Adenovirus

Reports summarize adenovirus research from Vrije University Amsterdam

Published in Vaccine Weekly, December 30th, 2009

"In vivo targeting of dendritic cells (DC) represents an attractive alternative to currently apply ex vivo DC-based genetic tumor vaccination protocols. Finding the optimal vector for in vivo targeting of DC is important for such strategies," scientists in Netherlands report.

"We, therefore, tested a panel of subgroup C/B chimeric and fiber-modified adenoviruses (Ads) for then relative capacity to transduce human DC. We made use of in vitro generated Langerhans cells, and of ex vivo human skin and melanoma-draining lymph node derived DC. Of the tested viruses the C/B-chimeric adenovirus serotype 5 (Ad5)/3 virus most efficiently transduced in vitro generated Langerhans...

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Source: Vaccine Weekly (2009-12-30)

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