Cancer Vaccines

Findings from University of Minnesota, Medical Department provide new insights into cancer vaccines

Published in Vaccine Weekly, January 6th, 2010

"Long-term treatment of mouse cancer cells with interferon-alpha (IFN-alpha) converts parental B16 melanoma cells to B16 alpha vaccine cells. Inoculation of syngeneic mice with UV-irradiated B16 alpha vaccine cells triggers immunity to the parental B16 tumor that is mediated by host macrophages, T cells, and NK cells," scientists in the United States report.

"Lymph node cells from mice inoculated with irradiated B16 alpha vaccine cells, but not with irradiated parental cells, proliferate when cultured in vitro, suggesting long-term in vivo activation of lymphoid cells. Both IL-15 mRNA and IL-15 protein are highly induced in B16 alpha vaccine cells. The bulk of the...

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Source: Vaccine Weekly (2010-01-06)

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