Vaccines
Studies in the area of vaccines reported from McMaster University
Published in Vaccine Weekly, January 6th, 2010
According to a study from Hamilton, Canada, "It is recognized that functional activities of antigen-presenting cells (APCs) in mucosal tissue sites differ from those of systemic APCs; however, it is unknown whether there are further differences between APC populations residing in different mucosal sites. In this study, we directly compared murine CD11c(+) APCs isolated from colon, lung, and spleen and found that APCs isolated from these tissues differ considerably in Toll-like receptor (TLR) expression and responses to in vitro TLR ligand stimulation."
"We also provide evidence that tissue microenvironments dictate distinct patterns of TLR expression by CD11c(+) APCs in...
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Source: Vaccine Weekly (2010-01-06)
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