Dengue Fever

New dengue fever research reported from J. Martin and co-authors

Published in Vaccine Weekly, January 20th, 2010

"Testing in non-human primates is a generally accepted necessary step preceding the evaluation of dengue vaccine candidates in humans. A reduction of viremia in these animals after virus challenge is generally used as an indicator of vaccine efficacy," researchers in Havana, Cuba report.

"In this work, we compared the infectivity of three strains of dengue virus type 2 in a non-human primate model of dengue infection, with the aim of selecting a virus for vaccine protection studies. As a result, strain SB8553 produced the longest duration of viremia, with a mean of 3 days/animal. In addition, it induced the highest antiviral and neutralizing antibody titers," wrote J....

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Source: Vaccine Weekly (2010-01-20)

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