Immunization
Research from S. Halle and co-researchers provides new data on immunization
Published in Vaccine Weekly, January 27th, 2010
"Mucosal vaccination via the respiratory tract can elicit protective immunity in animal infection models, but the underlying mechanisms are still poorly understood. We show that a single intranasal application of the replication-deficient modified vaccinia virus Ankara, which is widely used as a recombinant vaccination vector, results in prominent induction of bronchus-associated lymphoid tissue (BALT)," researchers in Hannover, Germany report.
"Although initial peribronchiolar infiltrations, characterized by the presence of dendritic cells (DCs) and few lymphocytes, can be found 4 d after virus application, organized lymphoid structures with segregated B and T cell...
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Source: Vaccine Weekly (2010-01-27)
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