Life Sciences
Investigators at Nihon University publish new data on life sciences
Published in Vaccine Weekly, February 10th, 2010
"In this study. we demonstrated that the 40-kDa outer membrane protein of Porphyromonas gingivalis (40k-OMP) sublingually administered with a cDNA vector plasmid encoding Flt3 ligand (pFL) elicited a protective immune response. Sublingual immunization of mice with 40k-OMP plus pFL induced significant serum IgG and IgA, as well as salivary IgA, antibody responses that were comparable to those induced by 40k-OMP plus cholera toxin as adjuvant," scientists writing in the journal Biochemical and Biophysical Research Communications report.
"When the subclasses of 40k-OMP-specific IgG were evaluated, sublingual immunization with 40k-OMP plus pFL induced both IgG1 and...
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Source: Vaccine Weekly (2010-02-10)
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