Published in Vaccine Weekly, February 17th, 2010
"Fe acquisition is a potential target for novel therapies. Gallium (Ga) is a transition metal that interferes with cellular Fe metabolism by competing with Fe for uptake/utilization. Growth of either F. tularensis live vaccine strain (LVS) or Francisella novicida was inhibited by >= 2 mc M Ga chelated to Tf or Lf, with GaLf...
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