Vaccinia
Research data from East Carolina University update understanding of vaccinia
Published in Vaccine Weekly, February 24th, 2010
Scientists discuss in 'Vaccinia virus A35R inhibits MHC class II antigen presentation' new findings in vaccinia. According to a study from the United States, "The Vaccinia virus gene A35R (Copenhagen designation) is highly conserved in mammalian-tropic poxviruses and is an important virulence factor, but its function was unknown. We show herein that A35 does not affect viral infectivity, apoptosis induction, or replication; however, we found that A35 significantly inhibited MHC class II-restricted antigen presentation, immune priming of T lymphocytes, and subsequent chemokine and cytokine synthesis."
"A35 localized to endosomes and reduced the amount of a model...
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Source: Vaccine Weekly (2010-02-24)
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