Meningococcal Vaccines

Researchers from Children's Hospital describe findings in meningococcal vaccines

Published in Vaccine Weekly, March 24th, 2010

A new study, 'Review of meningococcal group B vaccines,' is now available. According to recent research from the United States, "No broadly effective vaccines are available for prevention of group B meningococcal disease, which accounts for >50% of all cases. The group B capsule is an autoantigen and is not a suitable vaccine target."

"Outer-membrane vesicle vaccines appear to be safe and effective, but serum bactericidal responses in infants are specific for a porin protein, PorA, which is antigenically variable. To broaden protection, outer-membrane vesicle vaccines have been prepared from >1 strain, from mutants with >1 PorA, or from mutants with genetically...

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Source: Vaccine Weekly (2010-03-24)

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