Vaccines
Data from University of Quebec provide new insights into vaccines
Published in Vaccine Weekly, March 24th, 2010
A report, 'Canine distemper viruses expressing a hemagglutinin without N-glycans lose virulence but retain immunosuppression,' is newly published data in The Journal of Virology. "Paramyxovirus glycoproteins are posttranslationally modified by the addition of N-linked glycans, which are often necessary for correct folding, processing, and cell surface expression. To establish the contribution of N glycosylation to morbillivirus attachment (H) protein function and overall virulence, we first determined the use of the potential N-glycosylation sites in the canine distemper virus (CDV) H proteins," scientists in Laval, Canada report.
"Biochemical characterization...
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Source: Vaccine Weekly (2010-03-24)
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