Polio

Research findings from World Health Organization update understanding of polio

Published in Vaccine Weekly, March 24th, 2010

"A type 2 vaccine-related poliovirus (strain CHN3024), differing from the Sabin 2 strain by 0.44% in the VP1 coding region was isolated from a patient with vaccine-associated paralytic poliomyelitis," scientists writing in the journal Archives of Virology report.

"Sequences downstream of nucleotide position 6735 (3D (pol) coding region) were derived from an unidentified sequence; no close match for a potential parent was found, but it could be classified into a non-polio human enteroviruses species C (HEV-C) phylogeny. The virus differed antigenically from the parental Sabin strain, having an amino acid substitution in the neutralizing antigenic site 1. The...

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Source: Vaccine Weekly (2010-03-24)

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