Metabolism
Infectious Disease Research Institute describes research in metabolism
Published in Vaccine Weekly, April 21st, 2010
Researchers detail in 'Squalene-based oil-in-water emulsion adjuvants perturb metabolism of neutral lipids and enhance lipid droplet formation,' new data in metabolism. According to recent research from the United States, "Oil-in-water emulsions are used as vaccine adjuvants, but the mechanism of action remains unknown. In this paper we used phagocytes (monocytes, macrophages, dendritic cells) and non-phagocytic cells (fibroblasts, skeletal muscle cells) to study internalization of emulsions in vitro, and to characterize the influence of emulsion uptake on cellular metabolism of neutral lipids."
"We found that all tested cell types endocytose the emulsion droplets, and...
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Source: Vaccine Weekly (2010-04-21)
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