Fibrosis

New fibrosis study findings have been reported from E.P. Nadler et al

Published in Vaccine Weekly, May 12th, 2010

"Hepatic fibrosis leading to cirrhosis is the major morbidity in patients with biliary atresia (BA). This fibrosis is due to an imbalance in extracellular matrix (ECM) breakdown and deposition," scientists in the United States report.

"We have previously demonstrated increased mRNA expression for inhibitors of ECM breakdown without increased expression for mediators of ECM deposition in our animal model of BA by d 14. However, only a mild degree of hepatic fibrosis was seen at this time. We hypothesized that expression patterns for these proteins may change once more significant fibrosis had been established, and added resuscitation to the model to improve survival....

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Source: Vaccine Weekly (2010-05-12)

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