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Tuberculosis

Studies from Linkoping University in the area of tuberculosis described

Published in Vaccine Weekly, June 2nd, 2010

"Intracellular pathogens such as Mycobacterium tuberculosis have adapted to a life inside host cells, in which they utilize host nutrients to replicate and spread. Ineffective methods for the evaluation of growth of intracellular pathogens in their true environment pose an obstacle for basic research and drug screening," scientists in Sweden report.

"Here we present the validation of a luminometry-based method for the analysis of intramacrophage growth of M. tuberculosis. The method, which is performed in a medium-throughput format, can easily be adapted for studies of other intracellular pathogens and cell types," wrote D. Eklund and colleagues, Linkoping...

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