Virology

Research from N. Zhou and co-authors reveals new findings on virology

Published in Vaccine Weekly, June 16th, 2010

Investigators publish new data in the report 'Increased sensitivity of HIV variants selected by attachment inhibitors to broadly neutralizing antibodies.' "Treatment with HIV attachment inhibitors (AIs) can select for escape mutants throughout the viral envelope. We report on three such mutations: F423Y (gp120 CD4 binding pocket) and I595F and K655E (gp41 ectodomain)," scientists in the United States report.

"Each displayed decreased sensitivity to the AI BMS-488043 and earlier generation AIs, along with increased sensitivity to the broadly neutralizing antibodies 2F5 and 4E10, without affecting the rate of viral entry or sensitivity to the entry inhibitors AMD-3100 and...

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Source: Vaccine Weekly (2010-06-16)

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