Vaccinia Virus
Reports from University of Florida advance knowledge in vaccinia virus
Published in Vaccine Weekly, November 10th, 2010
New investigation results, 'Temperature-sensitive mutant in the vaccinia virus E6 protein produce virions that are transcriptionally inactive,' are detailed in a study published in Virology. "The vaccinia virus E6R gene encodes a late protein that is packaged into virion cores. A temperature-sensitive mutant was used to study the role of this protein in viral replicative cycle," scientists writing in the journal Virology report.
"Cts52 has a P226L missense mutation in the E6R gene, shows a two-log reduction in plaque formation, but displays normal patterns of gene expression, late protein processing and DNA replication during infection. Mutant virions...
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Source: Vaccine Weekly (2010-11-10)
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