Francisella

Study results from M.C. Parra and colleagues update understanding of francisella

Published in Vaccine Weekly, November 17th, 2010

According to recent research published in the journal Microbiological Research, "The severe and fatal human disease, tularemia, results from infection with the Gram-negative pathogen Francisella tularensis. Identification of surface outer membrane proteins, specifically lipoproteins, has been of interest for vaccine development and understanding the initiation of disease."

"We sought to identify Francisella live vaccine strain lipoproteins that could be a component of a subunit vaccine and have adjuvant properties as TLR2 agonists. We have identified a membrane lipoprotein of Francisella LVS isolated by sarkosyl extraction and gel filtration chromatography that...

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Source: Vaccine Weekly (2010-11-17)

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