Researchers detail in 'Novel application of Ki67 to quantify antigen-specific in vitro lymphoproliferation,' new data in interleukin-16 receptors. "Antigen-specific proliferation is a critical function of memory T cells that is often utilised to measure vaccineimmunogenicity and T cell function. We proposed that measurement of intracellular expression of the nuclear protein, Ki67, could reliably assess specific T cell proliferation in vitro," researchers in Cape Town, South Africa report.
"Ki67 was expressed in CD4+ and CD8+ T cells that had undergone in vitro proliferation after 6-day culture of human whole blood or PBMC with antigens. T cells cultured with no antigen...
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