Vaccines

Research on vaccines described by scientists at Anna University

Published in Vaccine Weekly, December 8th, 2010

2010 DEC 8 -- "Filarial nematodes down-regulate the host immune response to establish infection by inducing IL-10-mediated T-cell suppression. Abundant larval transcript (ALT) proteins are of major interest as they are expressed abundantly in the L3 stage, implicated in protective immunity and may play a role in immune evasion," researchers in Madras, India report.

"The T-cell epitopes of BmALT-2 and the cytokine responses induced by these peptides were investigated in a mouse model using synthetic peptides, which could be exploited in the design of a potent epitope-based vaccine. Five regions were found to carry T-cell epitopes inducing high levels of...

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Source: Vaccine Weekly (2010-12-08)

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