HIV/AIDS
Study findings from Tel Aviv University broaden understanding of HIV/AIDS
Published in Vaccine Weekly, December 29th, 2010
2010 DEC 29 -- Investigators publish new data in the report 'Antibodies and lentiviruses that specifically recognize a T cell epitope derived from HIV-1 Nef protein and presented by HLA-C.' "HIV selectively downregulates HLA-A and -B from the surfaces of infected cells to avoid detection by the immune system. In contrast, the HLA-C molecules are highly resistant to this downregulation," investigators in Tel Aviv, Israel report.
"High expression level of HLA-C on the cell surface, which correlates with a single nucleotide polymorphism, is also associated with lower viral loads and slower progression to AIDS. These findings strongly suggest that HIV-1-derived...
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Source: Vaccine Weekly (2010-12-29)
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