Immunization
New Immunization Findings from Technical University Munchen Published
Published in Vaccine Weekly, February 16th, 2011
2011 FEB 16 -- Research findings, 'Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody,' are discussed in a new report. "Immunization of mice with a 14-mer peptide TKDNNLLGRFELSG, termed 'TKD,' comprising amino acids 450-461 (aa(450-461)) in the C terminus of inducible Hsp70, resulted in the generation of an IgG1 mouse mAb cmHsp70.1. The epitope recognized by cmHsp70.1 mAb, which has been confirmed to be located in the TKD sequence by SPOT analysis, is frequently detectable on the cell surface of human and mouse tumors, but not on isogenic cells and normal tissues, and membrane Hsp70 might thus serve as a tumor-specific target structure,"...
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Source: Vaccine Weekly (2011-02-16)
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