2011 FEB 16 -- Research findings, 'Dendritic cells engineered to express GITRL enhance therapeuticimmunity in murine Lewis lung carcinoma,' are discussed in a new report. "Glucocorticoid-induced tumor necrosis factor receptor and its ligand (GITRL) are critically involved in the regulation of immune response. In this study, we aimed to generate bone marrow-derived dendritic cells (BMDCs) transfected with recombinantadenovirus expressing GITRL (pAd-GITRL-BMDCs) and explore their therapeutic efficacy in murine Lewis lung carcinoma," scientists in Zhenjiang, People's Republic of China report.
"In vitro, pAd-GITRL-BMDCs greatly enhanced effector T cells...
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