Colitis

Research in the Area of Colitis Reported from INSERM

Published in Vaccine Weekly, March 9th, 2011

2011 MAR 9 -- "Leukotriene B4 (LTB4) has chemotactic properties for activated T cells expressing the high-affinity receptor BLT1. This study investigated whether the LTB4 antagonist (CP-105,693), selective for BLT1 receptor, could protect mice from colitis mediated by specific cytotoxic CD8(+) T lymphocytes (CTL)," scientists writing in the journal Inflammatory Bowel Diseases report.

"Virus-specific colitis was induced in C57B1/6 mice transferred with lymphoid cells from P14 TcR Tg mice which are specific to class I GP33 peptide of LCMV. Mice were immunized with GP33-pulsed dendritic cells and colitis was elicited by intrarectal administration of the...

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Source: Vaccine Weekly (2011-03-09)

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