Streptococcus gordonii
Research Reports from Dalhousie University Provide New Insights into Streptococcus gordonii
Published in Vaccine Weekly, April 6th, 2011
2011 APR 6 -- "The charge density in the cell wall microenvironment of Gram-positive bacteria is believed to influence the expression of heterologous proteins. To test this, the expression of a SpaP-S1 fusion protein, consisting of the surface protein SpaP of Streptococcus mutans and a pertussis toxin S1 fragment, was studied in the live vaccine candidate bacterium Streptococcus gordonii," scientists in Halifax, Canada report.
"the parent strain PM14 expressed very low levels of SpaP-S1. By comparison, the dlt mutant strain, which has a mutation in the dlt operon preventing D-alanylation of the cell wall lipoteichoic acids, and another mutant strain,...
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Source: Vaccine Weekly (2011-04-06)
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