HIV/AIDS Vaccines

Study Findings from J.M. Milush et al Broaden Understanding of HIV/AIDS Vaccines

Published in Vaccine Weekly, April 27th, 2011

2011 APR 27 -- According to a study from Seattle, United States, "SIV infection of natural host species such as sooty mangabeys results in high viral replication without clinical signs of simian AIDS. Studying such infections is useful for identifying immunologic parameters that lead to AIDS in HIV-infected patients."

"Here we have demonstrated that acute, SIV-induced CD4(+) T cell depletion in sooty mangabeys does not result in immune dysfunction and progression to simian AIDS and that a population of CD3(+)CD4(-)CD8(-) T cells (double-negative T cells) partially compensates for CD4(+) T cell function in these animals. Passaging plasma from an SW-infected...

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Source: Vaccine Weekly (2011-04-27)

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