2011 MAY 4 -- Data detailed in 'Impaired immunogenicity of a meningococcal factor H-binding proteinvaccine engineered to eliminate factor h binding' have been presented. "Meningococcal factor H-binding protein (fHbp) is a promising antigen that is part of two vaccines in clinical development. The protein specifically binds human complement factor H (fH), which downregulates complement activation on the bacterial surface and enables the organism to evade host defenses," scientists in Oakland, United States report.
"In humans, the vaccine antigen forms a complex with fH, which may affect anti-fHbp antibody repertoire and decrease serum bactericidal activity...
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