Gene Therapy

Researchers from Mayo Clinic Discuss Findings in Gene Therapy

Published in Vaccine Weekly, May 4th, 2011

2011 MAY 4 -- "New therapeutic modalities for B-cell non-Hodgkin's lymphomas (B-NHL) are needed, especially for relapsing and aggressive subtypes. Toward this end, we previously generated a fully CD20-targeted and armed measles virus, and tested its efficacy in a xenograft model of mantle cell lymphoma (MCL)," scientists in Rochester, United States report.

"Here, we quantify its spread in peripheral blood mononuclear cells and/or tissue of patients with different histological subtypes of B-NHL, including splenic marginal zone lymphoma (SMZL). CD20-targeted MV efficiently infects lymphoma cells from SMZL and MCL while sparing most cells in the CD20-negative...

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Source: Vaccine Weekly (2011-05-04)

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