Granuloma

Reports Outline Granuloma Research from University of Virginia

Published in Vaccine Weekly, June 8th, 2011

2011 JUN 8 -- According to recent research from Charlottesville, United States, "Vasectomy is a well accepted global contraceptive approach frequently associated with epididymal granuloma and sperm autoantibody formation. To understand the long-term sequelae of vasectomy, we investigated the early immune response in vasectomized mice."

"Vasectomy leads to rapid epithelial cell apoptosis and necrosis, persistent inflammation, and sperm granuloma formation in the epididymis. Vasectomized B6AF1 mice did not mount autoimmune response but instead developed sperm antigen-specific tolerance, documented as resistance to immunization-induced experimental autoimmune...

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Source: Vaccine Weekly (2011-06-08)

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