Pneumonia
Study Findings on Pneumonia Are Outlined in Reports from University of Florence
Published in Vaccine Weekly, June 8th, 2011
2011 JUN 8 -- "Streptococcus pneumoniae expresses on its surface adhesive pili, involved in bacterial attachment to epithelial cells and virulence. The pneumococcal pilus is composed of three proteins, RrgA, RrgB, and RrgC, each stabilized by intramolecular isopeptide bonds and covalently polymerized by means of intermolecular isopeptide bonds to form an extended fiber," scientists writing in the Journal of Biological Chemistry report.
"RrgB is the pilus scaffold subunit and is protective in vivo in mouse models of sepsis and pneumonia, thus representing a potential vaccine candidate. The crystal structure of a major RrgB C-terminal portion featured...
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Source: Vaccine Weekly (2011-06-08)
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