Cancer Vaccines
Washington University School of Medicine Reports Research in Cancer Vaccines
Published in Vaccine Weekly, June 15th, 2011
2011 JUN 15 -- Research findings, "Identification of immunodominant HLA-B7-restricted CD8+ cytotoxic T cell epitopes derived from mammaglobin-A expressed on human breast cancers," are discussed in a new report. "Mammaglobin-A (MGBA), a 10-kD protein, is over expressed in 80% of primary and metastatic human breast cancers. Breast cancer patients demonstrate high frequencies of CD8(+) cytotoxic T lymphocytes (CTL) specific to MGBA," scientists writing in the journal Breast Cancer Research and Treatment report.
"Defining CD8(+) CTL responses to HLA class I-restricted MGBA-derived epitopes assumes significance in the context of our ongoing efforts to...
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Source: Vaccine Weekly (2011-06-15)
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