Vaccines
Data from University of Washington Advance Knowledge in Vaccines
Published in Vaccine Weekly, June 15th, 2011
2011 JUN 15 -- New investigation results, "Intracellular delivery of a protein antigen with an endosomal-releasing polymer enhances CD8 T-cell production and prophylactic vaccine efficacy," are detailed in a study published in Bioconjugate Chemistry. "Protein-based vaccines have significant potential as infectious disease and anticancer therapeutics, but clinical impact has been limited in some applications by their inability to generate a coordinated cellular immune response. Here, a pH-responsive carrier incorporating poly(propylacrylic acid) (PPAA) was evaluated to test whether improved cytosolic delivery of a protein antigen could enhance CD8+ cytotoxic lymphocyte...
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Source: Vaccine Weekly (2011-06-15)
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