Vaccinia Virus
Study Data from University of Pennsylvania Update Knowledge of Vaccinia Virus
Published in Vaccine Weekly, June 22nd, 2011
2011 JUN 22 -- Research findings, "Vaccinia virus D4 mutants defective in processive DNA synthesis retain binding to A20 and DNA," are discussed in a new report. "Genome replication is inefficient without processivity factors, which tether DNA polymerases to their templates. The vaccinia virus DNA polymerase E9 requires two viral proteins, A20 and D4, for processive DNA synthesis, yet the mechanism of how this tricomplex functions is unknown," scientists in Philadelphia, United States report.
"This study confirms that these three proteins are necessary and sufficient for processivity, and it focuses on the role of D4, which also functions as a uracil DNA...
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Source: Vaccine Weekly (2011-06-22)
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