Bacillus anthracis
Recent Findings in Bacillus anthracis Described by S.F. Little and Colleagues
Published in Vaccine Weekly, June 22nd, 2011
2011 JUN 22 -- According to a study from Fort Detrick, United States, "Protective antigen (PA) from Bacillus anthracis binds to cellular receptors, combines with lethal factor (LF) forming lethal toxin (LeTx), and facilitates the translocation of LF into the cytosol. LeTx is cytotoxic for J774A.1 cells, a murine macrophage cell line, and causes death of Fisher 344 rats when injected intravenously."
"PA is also the major protective component in anthrax vaccines. Antibody-dependent enhancement has been reported for several viral diseases, a bacterial infection, and for B. anthracis LeTx in vitro cytotoxicity. Further screening of our 73 PA monoclonal...
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Source: Vaccine Weekly (2011-06-22)
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